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Confocal microscopy also showed a reduction in elastosis and improved collagen fiber appearance.16 In another double-blind RCT (n=99), daily oral supplementation with 1g or 5g of collagen was associated with a significant increase in stratum corneum water content in both groups and a reduction in transepidermal water loss in the 5-mg group.17 Supplementation With Hydrolyzed Collagen for the Treatment of Skin Aging: Randomized Clinical Trials Not Included in or Published After the Meta-analysis by De Miranda et al.a (2021)

Notably, it has been investigated for its influence on cortisol and ACTH secretion rhythms in pre-clinical settings

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Marketing often highlights mean outcomes without acknowledging the 2030% of participants who experience minimal benefit or side effects limiting escalation to therapeutic doses